Haven't had that experience thankfully, except intermittently with things like feeds loading longer then usual every now and then. We work in a lot of instances. I wonder if there's something specific about your instance that has slowed down. There could be browser type things that slow down response times since Chronicle is very front-end heavy, for example I noticed that when I'm presenting it's EXTRA slow, but the minute i stop presenting it goes back to normal. Since you mention multiple people have that issue, could be something else entirely and may require some back and forth with support. 

The only issue I had was with hostname = "specific name in quotes". There was one specific instance that was running into issues with that but we had a hard time replicating on other instance. It doesn't seem like the issue on your end, i'm curious what does your browser say (what api endpoints load the slowest). Keep us posted in your investigation!